The BRAF Test for TCC in Dogs

As devoted pet parents, our dogs hold a special place in our hearts, and their health is always a top priority. When concerns about bladder cancer arise, it’s natural to feel worried and uncertain about what comes next.

Fortunately, advancements in veterinary medicine now offer innovative diagnostic tools that can provide early answers and peace of mind.

One such tool is the Cadet BRAF test, a cutting-edge diagnostic method designed to help detect transitional cell carcinoma (TCC)—the most common form of bladder cancer in dogs.

In this guide, we’ll explore what the BRAF test is, how it works, and what steps to take after receiving results.

🚨 Important: If you suspect a health issue in your pet, always consult your veterinarian for guidance.

What is the Cadet BRAF Test?

The Cadet BRAF test is a non-invasive diagnostic tool that helps detect bladder cancer in dogs, specifically TCC (transitional cell carcinoma).

It works by identifying a mutated BRAF gene, which is present in a high percentage of TCC cases.

🔬 How it works:
1️⃣ A urine sample is collected from your dog.
2️⃣ The sample is analyzed in a specialized laboratory to detect mutations in the BRAF gene.
3️⃣ If the mutation is present, it suggests a high likelihood of TCC, enabling early intervention.

Because early detection is crucial for managing and treating bladder cancer effectively, the Cadet BRAF test offers a fast, painless, and efficient way to screen for this disease.

What to Do If Your Dog Tests Positive for the BRAF Mutation

A positive BRAF test result means that the mutated BRAF gene has been found, which is strongly linked to TCC (bladder cancer). Here’s what to do next:

✔ Confirm with further testing – Additional diagnostic tests like ultrasound, X-rays, or cystoscopy can help locate the tumor and determine its extent.
✔ Consult a veterinary oncologist – A specialist can discuss treatment options and create a personalized care plan based on your dog’s overall health and cancer stage.
✔ Explore treatment options – Treatments may include:

• Surgery (if the tumor is small and operable)
• Chemotherapy (to slow cancer progression)
• Radiation therapy (to reduce tumor size and symptoms)
• Supportive care (pain management, dietary changes, holistic approaches like CBD)

The goal of treatment is to manage the cancer, reduce symptoms, and improve quality of life.

What to Do If Your Dog Tests Negative for the BRAF Mutation

A negative BRAF test result means that the mutation was not found in your dog’s urine sample. However, this does not completely rule out bladder cancer.

If your dog continues to show symptoms, consider the following:

✔ Further diagnostic tests – Additional tests like cytology or imaging (ultrasound, X-rays) may be needed to check for other potential causes of symptoms.
✔ Ongoing monitoring – Regular check-ups are essential, especially if symptoms persist or worsen.
✔ Preventive care – Lifestyle changes like increasing water intake, a specialized diet, and avoiding environmental toxins may help reduce cancer risk.

Other Ways to Test for Bladder Cancer in Dogs

While the BRAF test is one of the easiest and most cost-effective methods, there are other ways to confirm bladder cancer:

🩻 Imaging Tests – X-rays and ultrasound scans provide a visual look at the bladder, helping detect tumors or structural abnormalities.
📹 Cystoscopy – A tiny camera is inserted through the urethra to directly inspect the bladder lining and check for tumors.
🔬 Biopsy – A small tissue sample is taken from the bladder and examined under a microscope to confirm cancer.
🩸 Blood Tests – While not specific to bladder cancer, bloodwork can sometimes reveal abnormalities that suggest further testing is needed.

Why the Cadet BRAF Test is a Game-Changer

✔ Non-invasive – No surgery or sedation required—just a urine sample!
✔ Early detection – Helps identify bladder cancer before symptoms become severe.
✔ Faster diagnosis – Results are available sooner than traditional methods, allowing for quicker treatment decisions.

If you’re worried about bladder cancer in your dog, the Cadet BRAF test is an excellent first step toward early detection and peace of mind.

Always consult with your veterinarian about the best diagnostic approach for your pup’s unique needs.

References

Cancer Genome Atlas Research Network. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. (2014) 507:315–22. doi: 10.1038/nature12965

Decker B, Parker HG, Dhawan D, Kwon EM, Karlins E, Davis BW, et al. Homologous mutation to human BRAF V600E is common in naturally occurring canine bladder cancer-evidence for a relevant model system and urine-based diagnostic test. Mol Cancer Res. (2015) 13:993–1002. doi: 10.1158/1541-7786.MCR-14-0689

Fulkerson CM, Knapp DW. Management of transitional cell carcinoma of the urinary bladder in dogs: a review. Vet J. (2015) 205:217–25. doi: 10.1016/j.tvjl.2015.01.017